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Lack of functional Factor VIII is responsible for the disease Haemophilia A. In humans, Factor VIII is normally produced in the liver and transported into the bloodstream.
Until recently, Factor VIII for treatment of Haemophilia A was isolated from human blood. This carried the risk of potential transmission of infectious agents present in the donated blood.
Gene technology permits production of human Factor VIII of high quality in large amounts through the use of cultured cells. The procedure is safe and has now become routine.
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